PARTE UTILIZADA= Used part: Planta entera. 

ACCIÓN FARMACOLÓGICA= Pharmacological action: Estimulante, tónico, pectoral, afrodisíaco.

ZONA GEOGRÁFICA= Geografical zone: Brasil. 

ÚLTIMOS AVANCES EN LA QUÍMICA Y ACTIVIDADES BACTERIOLÓGICAS EN LAS PLANTAS MEDICINALES= Medicinal plants, last advances on chemistry and bacteria activities on the medicinal herbs

Ishigami et al. (Ishigami et al., 1998) reported that squalene monohydroperoxide (SQOOH) induced skin damage in hairless mice.  Kohno and Takahashi (Kohno and Takahashi, 1993) reported that SQOOH induced cytotoxicity against Chinese hamster lung fibroblasts.  We have already evaluated the efficacy of exts. obtained from Brazilian herbal medicines in protecting the normal human epidermis keratinocytes [NHEK(B)] against the cytotoxicity caused by SQOOH .  The EtOAc ext. was sepd. by silica-gel column chromatog. into eight fractions.  Fractions (Fr) 1,3 and 5 significantly protected rat basophilic leukemia (RBL-2H3) cells from the release of Beta-hexosaminidase due to SQOOH.  Addnl., Fr5-1 was most effective in a Gunze three-dimensional cultured human skin model (Vitrolife-skin) against the cytotoxicity due to SQOOH and the release of interleukin (IL)-2 and IL-4.  The mixt. of cinchonains Ia and Ib and the mixt. of cinchonains IIa and IIb were isolated from Fr3 and Fr5-1, resp.  The results suggest that the addn. of SQOOH caused the redn. in cell viability and the release of Beta-hexosaminidase and cytokines as chem. mediators.  The ext. of Catuaba (Anemopaegma mirandum) prevented these toxic effects with the main active agents suggested to be cinchonains IIa and IIb.

1) 270 (doscientos setenta) plantas medicinales iberoamericanas. Santiago de Bogotá : CYTED-SECAB, 1995, 617p.

2) UCHINO, T., et al. Potent protecting effects of Catuaba (Anemopaegma mirandum) extracts against hydroperoxide-induced cytotoxicity. Toxicology in Vitro. 2004, vol.18, nº3, p.255-263.